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Tomoki Todo Selected Research

Oncolytic Virotherapy

11/2021Oncolytic virotherapy with human telomerase reverse transcriptase promoter regulation enhances cytotoxic effects against gastric cancer.
9/2021Oncolytic herpes virus G47Δ works synergistically with CTLA-4 inhibition via dynamic intratumoral immune modulation.
8/2021Triple-mutated oncolytic herpes virus for treating both fast- and slow-growing tumors.
6/2021Oncolytic virotherapy with human telomerase reverse transcriptase promoter regulation enhances cytotoxic effects against gastric cancer.
2/2021Oncolytic virotherapy with SOCS3 enhances viral replicative potency and oncolysis for gastric cancer.
1/2021Oncolytic Virus Therapy with HSV-1 for Hematological Malignancies.
3/2019Oncolytic virus therapy in Japan: progress in clinical trials and future perspectives.
3/2018Third-generation oncolytic herpes simplex virus inhibits the growth of liver tumors in mice.
1/2017Current status of clinical trials assessing oncolytic virus therapy for urological cancers.
10/2016Oncolytic virus therapy: A new era of cancer treatment at dawn.
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Tomoki Todo Research Topics

Disease

36Neoplasms (Cancer)
08/2022 - 09/2002
15Glioma (Gliomas)
01/2022 - 12/2005
14Glioblastoma (Glioblastoma Multiforme)
11/2019 - 12/2005
6Brain Neoplasms (Brain Tumor)
11/2019 - 09/2005
5Stomach Neoplasms (Stomach Cancer)
11/2021 - 01/2013
4Melanoma (Melanoma, Malignant)
03/2019 - 07/2009
3Hepatocellular Carcinoma (Hepatoma)
11/2019 - 10/2016
3Astrocytoma (Pilocytic Astrocytoma)
02/2013 - 12/2005
2Herpes Simplex
01/2017 - 01/2006
2Prostatic Neoplasms (Prostate Cancer)
01/2010 - 11/2005
2Colonic Neoplasms (Colon Cancer)
07/2009 - 05/2005
1Central Nervous System Diseases (CNS Diseases)
08/2022
1Sarcoma (Soft Tissue Sarcoma)
06/2022
1Leiomyosarcoma
06/2022
1Carcinogenesis
01/2022
1Inflammation (Inflammations)
09/2021
1Plasma Cell Neoplasms
01/2021
1Bites and Stings (Sting)
01/2021
1Hematologic Neoplasms (Hematological Malignancy)
01/2021
1Lymphoma (Lymphomas)
01/2021
1Liver Neoplasms (Liver Cancer)
09/2020
1Neuroendocrine Tumors (Neuroendocrine Tumor)
12/2019
1Infections
01/2017
1Renal Cell Carcinoma (Grawitz Tumor)
01/2017
1Urologic Neoplasms (Urological Cancer)
01/2017
1Urinary Bladder Neoplasms (Bladder Cancer)
10/2016
1Head and Neck Neoplasms (Head and Neck Cancer)
10/2016
1Alopecia (Baldness)
11/2014
1Osteosarcoma (Osteogenic Sarcoma)
11/2014
1Epidural Neoplasms
11/2014
1Leukopenia
02/2013
1Lymphopenia (Lymphocytopenia)
02/2013

Drug/Important Bio-Agent (IBA)

6Proteins (Proteins, Gene)FDA Link
01/2019 - 12/2011
4Pharmaceutical PreparationsIBA
08/2022 - 10/2016
3Therapeutic UsesIBA
09/2021 - 11/2014
3talimogene laherparepvecIBA
03/2019 - 10/2016
3Temozolomide (Temodar)FDA LinkGeneric
01/2019 - 12/2017
2Telomerase (Telomerase Reverse Transcriptase)IBA
11/2021 - 06/2021
2Immune Checkpoint InhibitorsIBA
09/2021 - 10/2016
2EnzymesIBA
06/2021 - 09/2020
2AntigensIBA
01/2021 - 02/2008
2Antiviral Agents (Antivirals)IBA
01/2021 - 01/2017
2NigericinIBA
08/2018 - 10/2016
2RNA (Ribonucleic Acid)IBA
01/2018 - 01/2016
2VaccinesIBA
02/2013 - 02/2008
1ifenprodilIBA
08/2022
1Amoxapine (Asendin)FDA Link
08/2022
1DNA Methyltransferase 3AIBA
01/2022
1CytokinesIBA
02/2021
1Lenalidomide (CC 5013)FDA Link
01/2021
1NectinsIBA
01/2021
1Glycoproteins (Glycoprotein)IBA
01/2021
1Heparitin Sulfate (Heparan Sulfate)IBA
01/2021
1cyclic guanosine monophosphate-adenosine monophosphateIBA
01/2021
1InterferonsIBA
01/2021
1B7-H1 AntigenIBA
09/2020
1EphA1 Receptor (Eph Receptor)IBA
11/2019
1Bone Morphogenetic Proteins (Bone Morphogenetic Protein)IBA
11/2019
1Protein-Tyrosine Kinases (Tyrosine Kinase)IBA
11/2019
1ErythropoietinFDA Link
11/2019
1Histones (Histone)IBA
01/2019
1Lysine (L-Lysine)FDA Link
11/2018
1Sirtuin 2IBA
11/2018
1Reactive Oxygen Species (Oxygen Radicals)IBA
08/2018
1Calcium-Calmodulin-Dependent Protein Kinase KinaseIBA
08/2018
1CalciumIBA
08/2018
1epidermal growth factor receptor VIIIIBA
01/2018
1Phosphotransferases (Kinase)IBA
01/2018
1ErbB Receptors (EGF Receptor)IBA
01/2018
1Erlotinib Hydrochloride (CP 358,774)FDA Link
01/2018
1Fluspirilene (Imap)IBA
12/2017
1Antipsychotic Agents (Antipsychotics)IBA
12/2017
1Glycosylphosphatidylinositols (Glycosyl-Phosphatidylinositol)IBA
12/2017
1GTPase-Activating Proteins (GTPase-Activating Protein)IBA
01/2017
1Small Interfering RNA (siRNA)IBA
01/2017
1Adenosine Triphosphate (ATP)IBA
10/2016
1Mechanistic Target of Rapamycin Complex 1IBA
10/2016
1Ligases (Synthetase)IBA
10/2016
1TOR Serine-Threonine KinasesIBA
10/2016
1Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)IBA
10/2016
1RNA-Binding Proteins (RNA-Binding Protein)IBA
01/2016
1Amyloid Precursor Protein Secretases (beta-Secretase)IBA
01/2015
1MRK 003IBA
01/2015
15-hydroxymethylcytosineIBA
10/2014
1NimustineIBA
02/2013
1Procarbazine (Matulane)FDA Link
02/2013

Therapy/Procedure

26Therapeutics
08/2022 - 09/2002
17Oncolytic Virotherapy
11/2021 - 09/2002
6Drug Therapy (Chemotherapy)
06/2022 - 05/2005
3Injections
12/2021 - 06/2020
2Immunotherapy
10/2016 - 02/2008
2Radiotherapy
11/2009 - 12/2005
1Heterologous Transplantation (Xenotransplantation)
06/2022
1Neoadjuvant Therapy
09/2020
1Radiofrequency Ablation
09/2020
1Transplantation
01/2019
1Intralesional Injections
10/2016
1Boron Neutron Capture Therapy
11/2014
1Chemoradiotherapy
02/2013
1Adjuvant Chemotherapy
02/2013